Pharmacogenomics is a discipline studying the influence of genetic differences on drug effectiveness .It promises to op-timize the effect of medicine and reduce side effects .It is one of the most effective ways to predict the drug reaction in human body by using pharmacogenomics , which can achieve the goal of precision medicine .With the rapid development of the genetical test technolo-gies, the in vitro individual genome testing projects with the properties of high throughput , and measurable and low cost are better to be applied in medical practice and guiding for making individualized medicine plan .The study elucidated the progress in single nucleotide polymorphism and its clinical application , and focused on the strategic effects of pharmacogenomics on individualized treatment and gene diversity for guiding medicine .%药物基因组学是研究个体患者的遗传差异对药物作用的影响，继而优化药效并减少药物的不良反应的一门学科。利用基因组信息预测个体对药物的反应是实现个体化药物治疗最有效的途径之一，也是实现精准医疗的手段之一。随着基因检测技术的飞速发展，使得高通量、可衡量、低成本的体外个体基因组检测项目越来越多的应用到医疗实践中，指导制订个体化给药方案。本文介绍单核苷酸多态性以及相关临床应用进展，阐述药物基因组学的个体化治疗评价和其根据人体的基因多样性指导医疗的战略性作用。
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