辛伐他汀对高胆固醇血症患者脂肪细胞因子分布及安全性的影响

摘要

目的 探讨辛伐他汀对高胆固醇血症患者脂肪细胞因子分布及安全性的影响.方法 回顾性分析收治的242例高胆固醇血症患者,给予阿托伐他汀20mg进行治疗,比较治疗前与治疗后8周总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)水平的变化,对脂肪细胞因子瘦素、脂联素、肿瘤坏死因子α(TNF-α)水平的影响,以及分析治疗8周后不良反应发生情况.结果 治疗前与治疗后8周比较,TC(6.8,5.4),HDL-C(0.8,1.3),LDL-C(4.3,3.1),TG(1.9,1.6)水平均有显著改善,差异有统计学意义(P<0.05).治疗前与治疗后8周比较,瘦素(23.48,9.14)、脂联素(4.18,7.83)、TNF-α(1.83,1.15)水平均有显著改善,差异有统计学意义(P<0.05).不良反应发生率为1.24%(3/242),均不影响治疗,停药后即自行消失.结论 辛伐他汀可有效改善高胆固醇血症患者的血脂水平及细胞因子分布,安全性好.%Objective To explore the influence of simvastatin on the distribution and safety of adipocytokines in the patients with hypercholesterolemia. Methods 242 cases of hypercholesterolemia were performed the retrospective analysis. All cases were given simvastatin 20 mg. The changes of TC, HDL - C , LDL - C and TG levels and the influences on leptin, adiponectin and TNF -α levels were compared between before treatment and in 8 weeks after treatment. The adverse reactions after 8 - week treatment were analyzed. Results The levels of TC, HDL - C, LDL - C, TG were significantly improved with statistical differences between before treatment and after 8-week treatment (6.8 vs 5.4,0.8 vs 1.3,4.3 vs 3.1,1.9 vs 1.6,P < 0. 05 ). The levels of leptin, adiponectin and TNF -α were significantly improved with statistical differences between before treatment and after 8-week treatment (23.48 vs 9.14,4.18 vs 7.83,1.83 vs 1. 15, P < 0. 05 ). The occurrence rate of adverse reactions was 1.24% ( 3/242 ), which had no influence on treatment and disappeared spontaneously after drug withdrawal. Conclusion Simvastatin could improve the blood lipid level and the cytokines distribution with good safety.