阿托伐他汀钙对血脂异常高血压患者血脂及颈动脉内膜-中膜厚度的影响

摘要

Objective To explore the lipid modulation of atorvastatin calcium for the hypertension patients with abnormal blood lipid and its influence on the carotid intima-media thickness(IMT).Methods 350 hypertension patients with abnormal blood lipid were randomly divided into the control group(170 cases)and the observation group(180 cases).The control group was given the routine antihypertensive treatment,while th eobservation group received oral Atorvastatin Tablet based on the routine treatment.Blood pressure,blood lipid and IMT after treatment were compared between the two groups.Results There was no statistical difference in blood pressure after treatment between the two groups(P ＞ 0.05);TG,TC and LDL-C after treatment in the observation group were significantly lower than those in the control group(P ＜ 0.05);compared with the control group,IMT after treatment in the observation group was obviously decreased(P ＜ 0.05).Conclusion Atorvastatin calcium can greatly decrease the blood lipid,delay even reserve carotid atherosclerosis plaque for the hypertension patients with abnormal blood lipid,.%目的 探讨阿托伐他汀钙对血脂异常高血压病患者的调脂作用及对颈动脉内膜-中膜厚度(IMT)的影响.方法 将350例血脂异常高血压病患者随机分为对照组170例与观察组180例,对照组常规降压治疗,观察组患者在常规治疗基础上给予阿托伐他汀片口服.比较两组治疗后血压、血脂及IMT的差异.结果 治疗后两组血压无显著性差异(P＞0.05),观察组甘油三酯(TG)、总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)水平均显著低于对照组(P＜0.05)；与对照组相比,治疗后观察组IMT值显著下降(P＜0.05).结论 阿托伐他汀可显著降低血脂异常高血压患者血脂水平,延缓甚至逆转颈动脉粥样硬化斑块.