复方芪鹰颗粒联合α－硫辛酸对糖尿病周围神经病变的疗效及胰岛素样生长因子－1的影响

摘要

Objective To investigate the effect of adding Compound Qiying Granules in treating peripheral neuropathy and its influence on insulin-like growth factor-1. Methods 98 patients with diabetic peripheral neuropathy admitted to our hospital from August 2013 to March 2014 were selected and randomly divided into the observation group( n=52) and the control group( n=46). The control group was given the basic therapy,α-lipoic acid and mecobalamin,while on this basis the observation group was added with Compound Qiying Granules. The treatment course in the two groups was 20 d. The clinical effects were observed. The symptoms scores were com-pared between before and after treatment. The nerve conduction velocity and the level of insulin-like growth factor-1 were detect-ed. The occurrence situation of adverse drug reactions were recorded. Results The total effective rate after treatment in the observation group was 92. 31%,which was significantly higher than 76. 09% in the control group( P ﹤ 0. 05);the major symptom scores of lower limbs or foot pain,paresthesia,burning sensation and numbness after treatment in both the two groups were significantly lower than those before treatment( P ﹤ 0. 05),and the symptoms improvement of the observation group was more obvious( P ﹤ 0. 05);the EMG results showed that the improvement of nerve conduction velocity after treatment in the observation group was obviously better than that in the control group( P ﹤ 0. 05);the level of insulin-like growth factor-1 after treatment in the observation group was obviously higher than that in the control group( P ﹤ 0. 05);no apparent adverse reactions occurred during the treatment process in the two groups. Conclusion Adding Compound Qiying Granules has better clinical effect in treating diabetic peripheral neuropathy,and can promote the recovery of sensory and motor nerve conduction velocity,increases the level of insulin-like growth factor-1,which is worthy of clinical promotion.%目的：探讨加用复方芪鹰颗粒治疗糖尿病周围神经病变患者的疗效及对胰岛素样生长因子－1的影响。方法选择医院2013年8月至2014年3月收治的糖尿病周围神经病变患者98例，随机分为观察组52例和对照组46例。对照组给予基础治疗、α－硫辛酸和甲钴胺，观察组在对照组基础上加用复方芪鹰颗粒治疗，疗程均为20 d。观察临床疗效，治疗前后对症状进行评分，检测神经传导速度和血清胰岛素样生长因子－1水平，记录药品不良反应发生情况。结果观察组总有效率为92.31%，显著高于对照组的76.09%（ P ﹤0.05）；两组治疗后下肢或足部疼痛、感觉异常、灼热感及麻木等主要症状评分均明显低于治疗前（ P ﹤0.05），且观察组的各项症状改善效果更加明显（ P ﹤0.05）；肌电图检查结果显示，观察组治疗后神经传导速度改善效果明显好于对照组（ P ﹤0.05）；观察组治疗后血清胰岛素样生长因子－1水平明显高于对照组（ P ﹤0.05）；两组患者治疗过程中均未发生明显药品不良反应。结论加用复方芪鹰颗粒治疗糖尿病周围神经病变的临床疗效较好，能促进感觉和运动神经传导速度的恢复，升高胰岛素样生长因子－1水平，值得临床推广。