Combined use of pterostilbene and quercetin for the preparation of drugs for the treatment of cancer

摘要

The invention relates to the combined use of pterostilbene and quercetin for the production of cancer treatment medicaments. The in vitro growth of melanoma cells B16-F10 (B1611-F10) is inhibited (56%) by combined exposures of short duration (60 min/day) to PTER (40 µM) + QUER (20 µM) (- average values of plasma concentrations measured within the first hour following the IV administration of 20 mg of each polyphenol/kg -). The combined intravenous administration of PTER + QUER (20 mg/kg x day) to mice inhibits (73%) the metastatic growth of melanoma B16M-F10 in the liver, a common site for metastasis development. The invention demonstrates that the combination of PTER + QUER inhibits the growth of malignant melanoma metastasis and prolongs the survival of the carrier host.