热毒宁注射液联合宣白承气汤治疗老年慢性阻塞性肺疾病急性加重期疗效评价

摘要

目的：探讨热毒宁注射液联合宣白承气汤治疗老年慢性阻塞性肺疾病急性加重期（AECOPD）的疗效及其对炎症指标的影响。方法选取老年AECOPD患者60例，随机分为观察组和对照组，各30例。对照组患者给予西医常规治疗，观察组患者在对照组基础上加用热毒宁注射液联合宣白承气汤，均治疗7 d。结果治疗后，观察组总有效率为90.00%，高于对照组的70.00%（ P<0.05）；两组患者主要症状和体征积分均较治疗前明显降低，且观察组下降更明显（ P<0.05）；两组患者血pH均无明显变化（ P>0.05），二氧化碳分压( PaCO2)则显著下降、动脉血氧分压( PaO2)显著上升（ P<0.05），且观察组变化幅度均大于对照组（ P<0.05）；两组患者C反应蛋白（CRP）、降钙素原（PCT）水平均较治疗前下降，且观察组下降更明显（ P<0.05）；治疗过程中，两组患者均未发生严重不良反应。结论热毒宁注射液联合宣白承气汤治疗老年AECOPD，临床疗效良好，能显著改善症状、体征和血气指标，降低炎性反应，安全性高，值得推广。%Objective To investigate tbe clinical efficacy of Reduning Injection combined witb Xuanbaicbengqi Decoction in treating acute exacerbation of cbronic obstructive pulmonary disease(AECOPD)and its influence on inflammatory indexes. Metheods Totally 60 patients witb AECOPD were randomly divided into tbe observation group and tbe control group,30 cases in eacb group. Tbe control group was given western medicine routine treatment,on tbis basis tbe observation group was added witb Reduning Injection and Xuan-baicbengqi Decoction. Tbe two groups were treated for 7 d. Results After treatment,Tbe total effective rate in tbe observation group was 90. 00%,wbicb was significantly bigber tban 70. 00% in tbe control group ( P < 0. 05);tbe main symptoms and signs of inte-gration in tbe two groups were significantly decreased,moreover tbe decrease in tbe observation group was more significant( P < 0. 05);tbe cbanges of blood pH bad no significant difference before and after treatment( P > 0. 05),but PaCO2 decreased significantly,PaO2 increased significantly( P < 0. 05),moreover tbe varied range in tbe observation group was more remarkable( P < 0. 05);tbe CRP and PCT levels in tbe two groups were significantly decreased,moreover tbe decrease in tbe observation group was more significant( P < 0. 05);no serious adverse reaction occurred during tbe treatment course in tbe two groups. Conclusion Reduning injection combined witb Xu-anbaicbengqi decoction in treating elderly patients witb AECOPD bas good clinical efficacy,can significantly improve symptoms,signs and blood gas analysis,reduce inflammatory response witb bigb safety,and is wortb of clinical promotion.