二甲双胍对非酒精性脂肪肝患者肝脏组织学及超声影像学的影响

摘要

目的：探讨二甲双胍对非酒精性脂肪肝（NAFLD）患者肝脏组织学及超声影像学的影响。方法将118例患者随机分为对照组和观察组，各59例。两组患者均给予健康教育，对照组患者给予阿托伐他汀治疗，观察组患者在对照组治疗基础上加用二甲双胍，疗程均为8周。结果治疗后，观察组患者空腹血糖、胰岛素水平及胰岛素抵抗指数均较前明显下降（ P0.05）。结论二甲双胍能有效减轻NAFLD患者的胰岛素抵抗，对减轻肝细胞炎性反应和预防纤肝维化有明显作用，也能有效防止肝脏体积的增大，且不良反应较低，安全性良好。%Objective To investigate influence of metformin on liver bistology and ultrasonograpby in patients witb non-alcobolic fatty liver disease(NAFLD). Methods Totally 118 patients witb NAFLD were randomly divided into control group and observation group,59 cases in eacb group. Two groups of patients were giver bealtb education,on tbis basis tbe control group were treated witb atorvastatin, tbe observation group on tbe basis of control group were added metformin,tbe treatment course was 8 weeks. Results After treatment, tbe FPG,insulin levels and insulin resistance index in tbe observation group were significantly decreased tban before treatment( P 0. 05). Conclusion Met-formin can effectively reduce insulin resistance in patients witb NAFLD,reduce tbe inflammatory response of liver cells and prevent fi-brosis,and can effectively prevent tbe increase of tbe liver volume witb less adverse reactions and good safety.