肾素-血管紧张素系统( RAS)被认为参与了非酒精性脂肪性肝病(NAFLD)的发生、发展,阻断RAS的激活是治疗NAFLD的途径之一。血管紧张素-(1-7)[ Ang-(1-7)]是RAS的新成员,与血管紧张素Ⅱ(AngⅡ)相比,被认为可改善胰岛素抵抗、肝纤维化、脂质沉积及门静脉高压等。该文就Ang-(1-7)在NAFLD发病机制中的作用及其治疗前景进行综述,以探讨Ang-(1-7)能否成为治疗NAFLD的新方向。%The renin-angiotensin system ( RAS ) is considered to play an important role in the development and progression of nonalco-holic fatty liver disease ( NAFLD ) . The blocking of RAS activation is one of the pathways for treating NAFLD. Angiotensin-( 1-7 ) [ Ang-( 1-7 ) ] is recognized as one of the RAS new members. It is considered that compared with angiotensin Ⅱ ( Ang Ⅱ) , Ang-( 1-7 ) could ameliorate insulin resistance ( IR ) , hepatic fibrosis, lipid accumulation and portal hypertension, etc. This paper reviews the role of Ang-( 1-7 ) in the pathogensis of NAFLD and its therapeutical prospect in order to explore whether Ang-( 1-7 ) could become a new direction for treating NAFLD.
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