目的：评价两种方案治疗恶心呕吐的成本效果，促进临床合理、经济用药。方法回顾性分析2012年1月至2013年12月首次化疗的患者181例，分为两组，其中使用昂丹司琼静脉注射方案（A组）98例，使用托烷司琼静脉滴注（B组）83例。比较用药5 d后的疗效、不良反应和治疗成本，对两种方案进行药物经济学成本－效果分析。结果两组治疗方案的成本分别为1065.5元和861.0元；未呕吐率分别为47.96%和51.81%，未严重呕吐发生率分别为77.55%和77.11%，两组差异无统计学意义( P>0.05)。结论考虑药物的有效性、安全性，B组方案是治疗恶心呕吐的最佳治疗方案，更有经济学价值。%Objective To evaluate the cost-effectiveness of two schemes for treating nausea and vomiting in order to promote rational and economic drug use in clinic. Methods The retrospective analysis of 181 cases of the first time chemotherapy in our hospital from January 2012 to December 2013 were performed. The 181 cases were divided into two groups. 98 cases used ondansetron by intravenous drip ( group A ) and 83 cases used tropisetron by intravenous drip ( group B ) . The efficacy, adverse reactions and treatment costs after 5 d were compared between the two groups. The two kinds of medication scheme were performed the cost-effectiveness analysis. Results The costs for the two medication schemes were 1 065. 5 yuan and 861. 0 yuan respectively; the non-vomiting rates were 47. 96% and 51. 81% respectively, and the occurrence rate of non-severe and non-moderate vomiting were 77. 55% and 77. 11% respectively. There was no statistically significant difference in the cure rate between the two groups. Conclusion Considering the effectiveness and safety of drugs, the scheme in the group B is the better scheme with more economic value for treating nausea and vomiting.
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