目的:优选乌药中去甲异波尔定的提取工艺。方法采用正交试验设计,以去甲异波尔定提取率为考察指标,考察提取前浸泡时间、提取溶剂、提取方法、固液比、提取时间、提取温度等因素,同时测定干浸膏收率。结果最佳方案为提取前浸泡20 min,60%的乙醇水溶液提取溶剂,最终确定提取方法为超声提取、固液比1:12、提取时间为20 min、提取温度为45益。结论该方法简便、稳定、可行,可有效提取乌药中去甲异波尔定的含量,为以乌药为原料的抗宫炎系列药品提供质量控制依据。%Objective To optimize the optional extraction method of norisoboldine from Radix Linderae. Methods The content of norisoboldine was used as index to evaluate the technologies based on orthogonal design, considering ointment rate at the same time, in which the 6 factors were the soaking time before extraction, extraction solvent, extraction method, ratio of solid to liquid, extraction time, and extracting temperature. Results The optimum extraction processes was soaking for 20 min before extraction, 60% ethanol, ultrasonic extraction technique, solid-liquid ratio 1:12, the extraction time was 20 min, the extracting temperature was 45 ℃. Conclusion The method is simple, stable and feasible.
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