糖皮质激素在儿童呼吸道疾病中的应用状况与安全性分析

摘要

Objective To investigate the usage of glucocorticoid for pediatric respiratory disease in hospitalized children, and to under-stand its application status and safety, to provide information for improving children′s rational drug use. Methods A total of 5 633 copies of pediatric records in the hospital from September 2014 to August 2015 were collected and checked for the usage of glucocor-ticoid in the treatment of children with respiratory diseases, and the statistical analysis of drug use was conducted. Results In the total 5 633 cases, 3 137 cases were diagnosed with respiratory disease, 2 631 cases of which received glucocorticoid treatment, accounting for 83. 87%. The selection of variety, dosage, route of administration, the course of treatment of the glucocorticoid drugs were basically in line with the treatment principles, but there were also problems in clinical application process such as randomness, high DUI value, long course of treatment, and whether dexamethasone was suitable for inhalation, etc. Conclusion The doctors should strictly master the in-dications when using glucocorticoid for children, and make reasonable choice of drugs and proper use of glucocorticoid.%目的：调查儿科呼吸道疾病住院患儿糖皮质激素的使用情况，了解其应用状况与安全性，为提高儿童合理用药提供参考。方法选取2014年9月至2015年8月某院儿科的所有出院病历共5633份，查阅糖皮质激素在儿童呼吸道疾病治疗中的使用情况，并对用药情况进行统计与分析。结果在5633例患儿中，诊断为呼吸道疾病的患儿3137例，接受糖皮质激素治疗的呼吸道疾病患儿2631例，占呼吸道疾病患儿的83．87%。糖皮质激素类药物的品种选择、剂量、给药途径、疗程基本符合治疗原则，但临床应用过程也存在随意性较大、少数药物DUI值偏大、少数病例疗程偏长、地塞米松是否适用于雾化吸入等问题。结论医师在儿童中使用糖皮质激素时应严格掌握适应证，合理选择药物，适时、适量使用。