目的 探讨与研究在慢性鼻-鼻窦炎(chronic rhinosinusitis,CRS)治疗中使用口服糖皮质激素的安全性问题.方法 选择我院2016年5月~2017年3月收治的慢性鼻-鼻窦炎伴息肉(chronic rhinosinusitis with nasalpolys,CRSsNP)患者56例,其中35例研究组给予泼尼松40mg/d口服3天,20mg/d口服3天及10mg/d口服24天,并同时给予鼻用糖皮质激素(布地奈德)每天1次;21例作为对照组仅给予鼻用糖皮质激素(布地奈德)每天1次.两组疗程均为30天.随访观察药物不良反应并于停药后2月复查相关检验指标.结果 两组病例中均未出现严重不良反应.研究组出现的主要不良反应表现为胃肠道反应(5例)及失眠(3例).研究组用药前后肝肾功能无明显改变,对患者血压无明显影响,对血糖及血脂影响有限.结论 短期合理剂量口服糖皮质激素治疗CRS是安全的,可以作为有效的治疗方案.%Objective To investigate the safety of oral corticosteroids in the treatment of chronic rhinosinusitis (CRS). Methods Fifty-six patients with CRS and nasal polyps from May 2016 to March 2017 in our hospital were recruited, including 35 cases of the study group and 21 cases of the control group. Study group were given 40mg/d oral prednisone for 3 days, 20mg/d for 3 days and 10mg/d for 24 days, meanwhile they also received intranasal corticosteroid (budesonide) once a day. Control group only received intranasal corticosteroid (budesonide) once a day. The course of treatment was 30 days. We followed up the adverse reactions and reviewed the relevant indexes 2 months after the treatment. Results No severe adverse effects were found in this study. The main adverse effects of study group were gastrointestinal reaction (5 cases) and insomnia (3 cases). Blood pressure and the function of liver and kidney hadn't changed obviously. The influence of treatment on blood glucose and serum lipids were mild. Conclusion Short term oral corticosteroids for CRS is safe, which can be a clinical treatment option.
展开▼
