复方鱼腥草颗粒中连翘挥发油β－环糊精包合工艺优化研究

摘要

目的：用β－环糊精对复方鱼腥草颗粒中的连翘挥发油进行包合。方法采用正交试验法选择包合工艺的最佳条件，并对包合物的质量进行分析。结果得出的最佳工艺条件为挥发油与β－环糊精的比为10 mL∶80 g，包合时间为4 h，包合温度为60℃，加水量为β－环糊精的8倍。结论该包合工艺简单可行，可有效防止挥发油有效成分的散失。%Objective To clathrate the essential oil of Fructus Forsythian in Fufang Yuxingcao Granules with β-cyclodextrin. Methods The optimum condition for clathration craft was chosen by orthogonal tests and the quality of clathrates was analyzed. Results The op-timum craft condition:the proposition of essential oil and β-cyclodextrin was 10 mL ∶80 g;the process was 4 h at 60 °C;8 times of water respect to β-cyclodextrin was added. Conclusion The craft is proved to be simple,operatable and effective to avoid active gra-dients in the essential oil.