Objective To study the feasibility and safety of fasudil combined with α-lipoic acid for treating impotence. Methods A total of 84 patients with impotence diagnosed for the first time were randomly divided into the control group and the observation group, 42 cases in each group. The control group was given sildenafil orally,50 mg per time,1 d/time for 3 weeks,while the observation group was given 10 μg fasudil + 100 mL 0. 9％ Sodium Chloride Injection combined with 600 mg α-lipoic acid+250 mL 0. 9％Sodium Chloride Injection,ivgtt,1 d/time for 3 weeks. The efficacy and adverse reaction of the two groups were compared. Results Af-ter 3 weeks of treatment,there was no significant difference in the IIEF-5 scores and the hardness of penile erection between the two groups (P > 0. 05),after 3 months and 6 months follow-up,the IIEF-5 score and the hardness of penile erection of the observation group were significantly higher than those of the control group(P 0.05);随访3个月和6个月,观察组的IIEF-5评分和阴茎勃起硬度均明显高于对照组,差异有统计学意义(P<0.05);随访6个月,观察组的总有效率显著高于对照组,差异有统计学意义(P<0.05);两组均未出现严重不良反应.结论 法舒地尔联合α-硫辛酸治疗阳痿,有效性及安全性均较好.
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