目的：对2009~2013年麻腮风疫苗接种的不良反应统计分析，为今后的工作提供可靠的参考依据。方法检索中国知网、万方、维普等数据库的文献，对2009年1月~2013年12月间关于麻疹、腮腺炎、风疹疫苗接种不良反应报道进行统计，而后依据不良反应的发生于预防接种的因果关系对感染性不良反应和非感染性不良反应进行判断与分析。结果经统计发现，2009~2013年麻疹、腮腺炎和风疹的病例数逐渐增加，且本组三种疫苗接种不良反应报道地区分布较广，其中河南所占比例最高(30.0%)(P<0.05)，由麻疹减毒活疫苗和腮腺炎疫苗所引起的局部感染分别为2起和1起；麻疹、腮腺炎疫苗致死亡报道各1例；本组调查的数据中有1例儿童在接受麻疹减毒活疫苗后并发巨细胞间质性肺炎而死亡。结论目前的不良反应报道多为一般性病例报道，尚无准确、深入的流行病学调查研究，因此在今后的临床研究中，依据不良反应的发生与预防接种的因果关系对感染性不良反应和非感染性不良反应进行判断与分析意义重大，值得关注。%Objective To statistically analyze the adverse effects of inoculation of measles-mumps-rubella (MMR) vac-cine in 2009-2013,and to provide reliable references for future works. Methods Journal articles from literature databases such as cnki,wanfang,cqvip were searched,reports of adverse effects of inoculation of MMR vaccine from Jan-uary 2009 to December 2013 were collected,and infectious adverse effects and non-infectious adverse effects were judged and analyzed according to the causality of adverse effects and inoculation. Results Based on the statistics,the number of cases of MMR increased from 2009 to 2013,and the distribution of areas which reported the adverse effects of inoculation of three types of vaccines in this group was wide,in which the proportion in Henan was the highest (30.0%) (P<0.05).Local infections induced by measles attenuated live vaccine and mumps vaccine were seen in two cases and one case respectively;one deceased case each was reported in measles vaccine and mumps vaccine;one chil-dren in the investigated data died of complicated giant cell interstitial pneumonia after the inoculation of measles atten-uated live vaccine. Conclusion The majority of current reports of adverse effects are general case reports,without accu-rate and deep epidemiological investigation.In the future clinical research,therefore,there is of great significance in the judgment and analysis of infectious adverse effects and non-infectious adverse effects according to the causality of ad-verse effects and inoculation,which deserves to be paid close attention.
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