地佐辛复合酮咯酸氨丁三醇在胸科术后静脉自控镇痛中的应用效果

摘要

目的：探讨地佐辛复合酮咯酸氨丁三醇在胸科术后静脉自控镇痛(PCIA)中的应用效果。方法选择ASA分级I~Ⅱ级、胸科肺大泡切除术患者40例，随机分为两组，每组20例。I组采用地佐辛30 mg加酮咯酸氨丁三醇150 mg，Ⅱ组采用芬太尼1 mg。两组均用生理盐水稀释至200 ml。手术后接PCIA泵，设置负荷剂量10 ml，持续给药量3 ml/h，自控量4 ml/20 min，记录两组视觉模拟评分(VAS)和Ramsay评分，比较两组镇痛满意度、PCIA泵按压次数和不良反应。结果两组术后VAS、Ramsay及Likert评分比较，差异均无统计学意义(P>0.05)。两组不良反应发生率比较差异有统计学意义(P<0.05)。两组PCIA泵药物用量及使用次数的比较差异均无统计学意义(P>0.05)。结论地佐辛复合酮咯酸氨丁三醇应用于胸科术后PCIA效果确切，安全性高，且不良反应发生少。%Objective To investigate application effect of dezocine combined with ketorolac tromethamine in thoracic postoperative patient-controlled intravenous analgesia. Methods 40 patients in ASAⅠ-II with chest operation resec-tion of lung bullae were selected and randomly divided into two groups,20 patients in each group.Dezocine 30 mg and ketorolac tromethamine 150 mg were used in groupⅠ,while fentanyl 1 mg in groupII.The two groups of drug were di-luted to 200 ml with NS,and the patient-controlled intravenous analgesia pump was set with loading dose 10 ml,contin-uous dosage 3 ml/h,self-control was 4 ml/20 min.The visual analogue score (VAS)and the Ramsay score were recorded, analgesic satisfaction and the pressing frequency of patient-controlled intravenous analgesia pump,adverse reaction were compared. Results The postoperative VAS,Ramsay score and Likert score in two groups was compared respective-ly,with no statistical difference(P>0.05).The incidence rate of adverse reaction in two groups was compared,with statisti-cal difference (P<0.05).The drug dosage and use frequency of patient-controlled intravenous analgesia pump in two groups was compared respectively,with no statistical difference(P>0.05). Conclusion Dezocine combined with ketorolac tromethamine applied in patient-controlled intravenous analgesia after thoracic surgery can provide exact effection,has high safety and less adverse reaction.