FPG、HbA1c检测在重症颅脑外伤急性期病情评估及预后判断中的价值

摘要

目的探讨空腹血糖(fasting plasma glucose,FPG)与糖化血红蛋白(glycosylated hemoglobin A1c,HbA1c)检测在重症颅脑外伤急性期病情评估及预后判断中的应用价值. 方法 随机选取2012年12月~2014年12月期间我院收治的40例颅脑损伤患者,根据患者入院时的格拉斯哥昏迷指数评分将其分为重度颅脑外伤患者(观察组)和轻度颅脑外伤患者(对照组),每组各20例,分别对其进行空腹血糖(FPG)、糖化血红蛋白(HbA1c)的检测,对比分析两组患者的FPG水平和HbA1c水平与患者急性期病情评估及预后判断的关系. 结果 观察组的平均空腹血糖水平明显高于对照组,糖化血红蛋白水平较高的颅脑外伤患者病死率明显高于糖化血红蛋白水平低者(P<0.05). 结论 重度颅脑外伤患者急性期的空腹血糖及糖化血红蛋白水平是判断其颅脑损伤严重程度的重要参考指标,也为患者的预后判断提供了较准确的数据指标,具有良好的参考价值.%Objective To explore and analyze the application value of fasting blood glucose(FPG) detection and glyco-sylated hemoglobin A1c (HbA1c) detection in assessment and prognosis of severe traumatic brain injury at acute stage. Methods A total of 40 cases of patients with traumatic brain injury who were admitted to our hospital from December 2012 to December 2014, were randomly selected, according to the Glasgow Coma Scale score on admission, and they were divided into severe traumatic brain injury patients group and mild traumatic brain injury patients group, each group with 20 cases. Fasting plasma glucose(FPG) and glycosylated hemoglobin(HbA1c) were conducted in patients of the two groups respectively, and the relationship between FPG levels and HbA1c levels of patients in the two groups and assessment and prognosis of patients with severe traumatic brain injury at acute stage was compared and analyzed. Results The mean fasting plasma glucose levels(FPG) in patients with severe traumatic brain injury were significantly higher than those in patients with mild traumatic brain injury, and mortality of high glycated hemoglobin lev els in patients with traumatic brain injury was significantly higher than that in patients with low hemoglobin levels(P<0.05). Conclusion Fasting blood glucose and glycated hemoglobin levels are important reference index to determine the severity of brain injury for severe brain injury patients at acute stage, but also provide a more accurate indicator for the prognosis of patients, and have good reference value.