肺癌治疗与真菌感染相关性分析

摘要

Objective To analyze the correlation between lung cancer treatment and fungal infection.Methods Altogether 2083 patients with lung cancer were enrolled in this retrospective study.The patients wereclassified by methods of therapy,including operative group and non-operative group,antibiotic group and non-antibiotic group,radiotherapy group,chemotherapy group,radiochemotherapy group,hormone group and cathetertherapy group.Results Out of the 2083 patients,14.16%were diagnosed of airway fungal infection.The differenceof infection rate was not significant between operation group and non-operation group(P＞0.05).Among the operationgroup,the Ⅳ phase cancer patients had significantly higher infection rate than Ⅲ phase patients(P＜0.01).Thepatients who had received chemotherapy,or combination of chemotherapy and radiotherapy had a higher infection ratethan those who received radiotherapy only(P＜0.05).Those who received antimierobial treatment had a higherinfection rate than those who received antimicrobial propbylaxis(P＜0.05).Specifically,the more antimicrobials Wasused,the more significant the difference was(P＜0.01).Conclusion The incidence of fungal infection in lungcancer patients is related to the use of antibiotics,chemotherapy,operation,hormone therapy and catheter therapy.%目的 探讨肺癌治疗与真菌感染之间的关系.方法 2083例肺癌患者按治疗方法分别进行分组,包括手术与非手术组,放疗组、化疗组和放疗化疗组,治疗感染组和预防感染组.分析各治疗方法中导致真茵感染因素并做统计学处理.结果 肺癌患者的真茵感染率14.16%,手术组与非手术组感染率无统计学意义(P＞0.05),手术组内Ⅲ、Ⅳ期之间有统计学意义(P＜0.01),Ⅲ、Ⅳ期手术组和非手术组有统计学意义(P＜0.01),化疗组,放疗化疗组与放疗组有统计学意义(P＜0.05),化疗组和放疗化疗组无统计学意义(P＞0.05),治疗感染组和预防感染组有统计学意义(P＜0.05),治疗感染组和预防感染组内随着联合用药的增加差异有统计学意义(P＜0.01).结论 肺癌患者Ⅲ、Ⅳ期手术,化疗,联合应用抗生素,激素、导管侵入治疗可增加其真菌的感染率.