肿瘤坏死因子α及淀粉酶对重症急性胰腺炎外科重症监护的临床干预及其效果评价

摘要

目的 评价肿瘤坏死因子α(TNF-α)以及血、尿淀粉酶在外科ICU对重症急性胰腺炎患者临床干预的效果.方法 回顾性分析我院外科ICU收治的32例急性重症胰腺炎患者,经我院外科ICU监护及治疗,比较治疗前后各组的TNF-α以及淀粉酶的结果.结果 32例患者在临床干预后,TNF-α的曲线下面积为0.94,灵敏度为97%,特异度为90%;血淀粉酶的曲线下面积为0.89,灵敏度为93%,特异度为85%;尿淀粉酶的曲线下面积为0.87,灵敏度为75%,特异度为96%.结论 TNF-α比淀粉酶能更好地用于评价急性重症胰腺炎患者的临床干预效果.%Objective To evaluate the effect of clinical intervention of severe acute pancreatitis on tumor necrosis factor-α(TNF-α),serum and urine amylase in surgical intensive care unit (SICU).Methods Thirty-two severe acute pancreatitis patients accepted in SICU were retrospectively analyzed.Levels of TNF-α and amylase were compared.Results After a 10-day observation,3 cases were cured and 3 cases had whole brain death.The area under curve (AUC) of TNF-α was 0.94,the sensitivity was 97% and the specificity was 90%.The AUC of serum amylase was 0.89,the sensitivity was 93% and the specificity was 85%.The AUC of urine amylase was 0.87%,the sensitivity was 75% and the specificity was 96%.Conclusion Compared with amylase,TNF-α can be a superior evaluation index of clinical intervention on severe acute pancreatitis patients in SICU.