风湿痛消丸的临床疗效观察

摘要

Objective To observe the levels of IL-1, TNF-α, IL-4 and IL-10 in serum of patients with rheumatoid arthritis(RA). Methods Totally 60 cases were randomly divided into Feng Shi Tong Xiao Pill group and Glucosida Tripterygii TOTA group given Glucoside Tripterygium Total auspended matter. Thirty normal people who were done health check-ups in control group. Levels of IL-1, TNF-α, IL-4 and IL-10 in patients with RA were measured by enzyme-linked immunoabsorbent assay. Results Before medicine administration, the levels of IL-1,IL-4, IL-10and TNF-α were significantly different between patients with RA and blank group (P ＜ 0.05). After medicine administration, the levels of IL-1, IL-4, IL-10and TNF-α were not significantly different between patients with RA and blank group(P ＞ 0.05). Conclusion Feng Shi Tong Xiao Pill can improve RA.%目的 观察风湿痛消丸对类风湿关节炎患者血清中自细胞介素(IL)-1、肿瘤坏死因子(TNF)-α、IL-4和IL-10的影响.方法 将60例类风湿关节炎患者完全随机分为2组,雷公藤多甙组30例,给予雷公藤多甙片进行治疗;风湿痛消丸组30例,给予风湿痛消丸进行治疗;对照组30例为我院正常体检健康者,应用酶联免疫吸附法(ELISA)检测各组患者IL-1、TNF-α、IL-4和IL-10的水平.结果 给药前雷公藤多甙组与风湿痛消丸组患者血清中IL-1和TNF-α水平与对照组比较都有明显升高[IL-1:(72.3±9.4)ng/L、(70.5±10.4)ng/L比(9.9±2.4)ng/L;TNF-α:(109.4±14.5)ng/L、(110.3±13.2)ng/L比(12.6±1.7)ng/L;P＜0.05],IL-4和IL-10的水平与对照组比较有明显下降[IL-4:(30.2±6.8)ng/L、(27.4±7.4)ng/L比(125.3±13.2)ng/L;IL-10:(9.6±2.2)ng/L、(9.8±1.4)ng/L比(60.3±7.4)ng/L;P＜0.05];给药后雷公藤多甙组和风湿痛消丸组患者各项指标与对照组相比,差异无统计学意义(P＞0.05).结论 风湿痛消丸对类风湿关节炎有明显的治疗作用.