白细胞介素1β基因+3954T/C多态性与乳腺癌易患性相关性研究

摘要

目的 探讨白细胞介素1β(IL-1β)基因+3954T/ C 多态性与乳腺癌易患性之间的关系.方法乳腺癌组为符合纳入标准并病理学确诊的乳腺癌新发病例223例,对照组为体检中心常规体检的健康女性284例,采用静脉采血分析各项指标后进行统计学分析.结果 IL-1β+3954(rs1143634)和IL-1RN基因及基因型的频率在乳腺癌组与对照组之间差异无统计学意义(P＞0.05);在肿瘤增殖抗原(ki67)的乳腺癌组中,IL-1β+3954(rs1143634)位点的C,T转换明显增高[C:96.5%(301/312)比88.8%(119/134);T:3.5%(11/312)比11.2%(15/134),P＜0.05];在雌激素受体阴性的乳腺癌患者T等位基因的比例增高,差异有统计学意义[23.0%(32/139)比4.5%(15/332),P＜0.05].结论 IL-1β基因+3954T/ C多态性与乳腺癌的易感性无相关性,但在ki67高指数的乳腺癌组中,IL-1β+3954(rs1143634)位点的C-T转换明显增高,在雌激素受体阴性和人表皮生长因子受体2-的乳腺癌患者中A2的比例增高,SNP可能与乳腺癌的不同分子类型相关.%Objective To observe the correlation between the polymorphism of IL-1β gene and the susceptibility of the breast cancer. Methods The experimental group had 223 cases who were diagnosed as new breast cancer by pathology; the control group had 284 cases who were healthy. The data were analyzed by the questionnaire survey and analyzed them by statistics. Results The gene and genotype of IL -1β+3954(rs1143634) and IL-1RN were the same in the two groups (P>0.05), but in the high ki-67 group, the IL -1β+3954(rs1143634) locus's C-T change had significant differences [C:96.5%(301/312) vs 88.8%(119/134); T:3.5%(11/312) vs 11.2%(15/134),P＜0.05].Conclusion There is not correlation between the polymorphism of IL-1β gene +3954T/ C and the susceptibility of the breast cancer in the northwest China, but in the high ki-67 group, the locus's C-T change is significantly increased, in the ER- group the portion of A2 is significantly increased. This suggests that it is positive correlation that IL-1B gene +3954 T/C polymorphism and high recurrence of risk groups in ER- and KI-67 high expression.