Objective To analyze risk factors of hypertension disorder complicating pregnancy.Methods Three hundred and sixty-three cases of hypertension disorder complicating pregnancy from January 2012 to July 2015 in Beijing Anzhen hospital,Capital Medical University were enrolled as the observation group.Three hundred and sixty healthy pregnant women(collected from Beijing Anzhen hospital) with same pregnant and perinatal period were enrolled as the control group.General clinical data were recorded,including elderly pregnancy,hypertension history,diabetes history,heart disease history,binocular high myopia,obesity (body mass index ≥28 kg/m2),thyroid dysfunction,malnutrition,pulmonary arterial hypertension,kidney disease and dyslipidemia.Risk factors of hypertension disorder complicating pregnancy were analyzed.Results There were significant differences of proportions of elderly pregnancy,hypertension history,diabetes history,heart disease history,obesity,thyroid dysfunction,malnutrition,pulmonary arterial hypertension,kidney disease and dyslipidemia between the observation group and the control group [10.5％ (38/363) vs 3.6％ (13/360),5.2％ (19/363) vs 1.9％(7/360),16.5％ (60/363) vs 10.0％ (36/360),8.3％ (30/363) vs 1.1％ (4/360),7.2％ (26/363) vs 0.8％ (3/360),11.0％ (40/363) vs 1.1％ (4/360),9.9％ (36/363) vs 2.2％ (8/360),2.2％ (8/363) vs 0.0％ (0/360),8.3％ (30/363) vs 2.5％ (9/360),7.2％ (26/363) vs 0.3％ (1/360)] (all P ＜0.05).Univariate logistic analysis showed that elderly pregnancy[odds ratio(OR) =3.1,95％ confidence interval(CI):1.6-6.0],hypertension history(OR =2.8,95％CI:1.2-6.7),diabetes history(OR =1.8,95％ CI:1.1-2.8),obesity (OR =9.2,95％ CI:2.8-30.6),heart disease history (OR =11.0,95％ CI:3.9-31.1),malnutrition (OR=4.8,95％CI:2.2-10.6),kidney disease(OR=3.5,95％CI:1.6-7.5) and dyslipidemia(OR =27.7,95％ CI:3.7-205.1) were risk factors of hypertension disorder complicating pregnancy.Conclusion Elderly pregnancy,hypertension history,diabetes history,obesity,heart disease history,malnutrition,kidney disease and dyslipidemia are risk factors of hypertension disorder complicating pregnancy.%目的 探讨妊娠期高血压疾病的危险因素.方法 选取2012年1月至2015年7月于首都医科大学附属北京安贞医院住院分娩的妊娠期高血压疾病产妇363例作为观察组,选取同期孕周匹配的正常产妇360例为对照组.比较2组患者一般资料,包括高龄(≥35岁)、高血压病史、糖尿病史、心脏病史、高度近视(双眼)、肥胖症(体重指数≥28 kg/m2)、甲状腺功能异常、营养不良、肺动脉高压、肾脏疾病和脂代谢异常,分析妊娠期高血压疾病的危险因素.结果 观察组与对照组高龄、高血压病史、糖尿病史、心脏病史、肥胖症、甲状腺功能异常、营养不良、肺动脉高压、肾脏疾病和脂代谢异常者所占比例比较[10.5％(38/363)比3.6％ (13/360)、5.2％(19/363)比1.9％ (7/360)、16.5％(60/363)比10.0％ (36/360)、8.3％(30/363)比1.1％ (4/360)、7.2％ (26/363)比0.8％ (3/360)、11.0％(40/363)比1.1％ (4/360)、9.9％(36/363)比2.2％ (8/360)、2.2％(8/363)比0.0％(0/360)、8.3％ (30/363)比2.5％ (9/360)、7.2％(26/363)比0.3％ (1/360)],差异均有统计学意义(均P＜0.05).单因素Logistic回归分析显示高龄[比值比(OR)=3.1,95％置信区间(CI):1.6～6.0]、高血压病史(OR=2.8,95％ CI:1.2～6.7)、糖尿病史(OR=1.8,95％ CI:1.1～2.8)、心脏病史(OR=11.0,95％ CI:3.9～31.1)、肥胖症(OR =9.2,95％ CI:2.8 ～30.6)、营养不良(OR=4.8,95％CI:2.2～10.6)、肾脏疾病(OR =3.5,95％ CI:1.6～7.5)和脂代谢异常(OR =27.7,95％ CI:3.7 ～205.1)是妊娠期高血压疾病的危险因素(均P＜0.05).结论 高龄、高血压病史、糖尿病史、心脏病史、肥胖症、营养不良、肾脏疾病及脂代谢异常为妊娠期高血压疾病的危险因素.
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