碱性成纤维细胞生长因子和转化生长因子-β与病理性近视的相关研究

摘要

Objective To explore the expression of bFGF and TGF-β and the relationship with pathological myopia. Methods The level of bFGF and TGF-β were detected in patients with pathological myopia and non-pathological myopia and healthy controls. Results The expression level of bFGF were lower in patients with pathological myopia than non-pathological myopia andhealthy controls,and the expression level of TGF-β were higher in patients with pathological myopia than non-pathological myopia and healthy controls,the difference was significant(P < 0.01). Conclusion Conclusion bFGF and TGF-β may play a certain role in the occurrence and development of pathological myopia.%目的：探讨病理性近视患者 bFGF 和 TGF-β的表达水平。方法对我院门诊就诊的病理性近视患者、非病理性近视患者和正常对照组的 bFGF 和 TGF-β的表达水平进行检测，探讨其在病理性近视患者和非病理性近视患者中的表达强度。结果与正常对照组比较，病理性近视和非病理性近视患者血中bFGF 表达明显低于正常对照组，而这两组患者血中 TGF-β的表达明显高于正常对照组，差异具有统计学意义（P ＜0.01）。结论 bFGF 和 TCF-β可能在病理性近视的发生发展过程序中发挥着一定的作用。