RCAS1和CD105在胸腔积液中的表达及临床意义

摘要

Objective To study the expression and clinical significance of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) and CD105 in different types of pleural effusion. Methods 76 cases of patients with pleural effusion were divided into malignant pleural effusion group (40 cases) and tuberculous pleural effusion group (36 cases) according to the pathological type. The level of RCAS1 and CD105 concentrations of serum and pleural fluid from patients with malignant pleural effusion and tuberculous pleural effusion were measured by the enzyme linked immunosorbent assay (ELISA), the difference were analysed. Results The level of serum RCAS1 (36.1988±5.6195) U/mL and CD105 (6.2090±0.2608)μg/L of patients with malignant pleural effusion were higher than that of tuberculous pleural effusion[(13.6022±3.2608) U/mL, (5.1536±0.1872) μg/L]. The level of pleural effusion RCAS1(50.3008±5.3298) U/mL and CD105 (4.1133±0.1695) μg/L of patients with malignant pleural effusion were higher than that of tuberculous pleural effusion[(21.1433±3.1365) U/ml, (3.2492±0.1305) μg/L] (P < 0.01). Conclusion Examination of RCAS1 and CD105 in serum and pleural fluid has a certain clinical application value in differential diagnosis of patients with tuberculous pleurisy and malignant pleurisy.%目的：研究癌性胸水和结核性胸水患者血清及胸水中 SiSo 细胞表达的受体结合肿瘤抗原（RCAS1）和 CD105的表达水平和临床意义。方法根据病理类型将76例胸腔积液患者分为恶性胸腔积液（癌性组）40例和结核性胸腔积液患者（结核组）36例，应用酶联免疫吸附试验法（ELISA）分别对两组血清及胸水中的 RCAS1和 CD105的水平进行检测，比较两组血清和胸水中 RCAS1和 CD105表达水平的差异以及两者与临床之间的关系。结果40例恶性胸腔积液（癌性组）血清及胸水中 RCAS1和 CD105表达水平均高于36例结核性胸腔积液患者（结核组），癌性胸腔积液患者和结核性胸腔积液患者血清中 RCAS1水平分别为（36.1988±5.6195）U/mL 和（13.6022±3.2608）U/mL，癌性胸腔积液患者和结核性胸腔积液患者血清中CD105的水平分别为（6.2090±0.2608）μg/L 和（5.1536±0.1872）μg/L，癌性胸腔积液患者和结核性胸腔积液患者胸水中 RCAS1水平分别为（50.3008±5.3298）U/mL 和（21.1433±3.1365）U/mL，癌性胸腔积液患者和结核性胸腔积液患者胸水中 CD105的水平分别为（4.1133±0.1695）μg/L 和（3.2492±0.1305）μg/L，两者相比差异有统计学意义（P ＜0.01）。结论监测胸腔积液患者血清和胸水中 RCAS1和 CD105的表达水平对恶性胸腔积液和结核性胸腔积液的鉴别诊断有一定的临床应用价值。