CD105 Biomarker composition for isolating fibroblast with capacity of multipotency comprising CD105 and method for isolating fibroblast with capacity of multipotency using the same marker

摘要

The present invention relates to a biomarker composition for the isolation of fibroblasts having stem cell function including CD105, and a method for separating fibroblasts having stem cell function using the same. Provides CD105 antibodies as biosurfactant markers useful for assessing selective isolation of fibroblasts with stem cell potential. According to the present invention, fibroblasts isolated from mouse skin dermis cells are not CD73-expressing, and are confirmed to be differentiated from mesenchymal stem cells by confirmation of fibroblast-specific marker expression. In addition, CD105 positive and negative fibroblasts were separated by CD105 surface marker expression in a continuous subculture, and CD105-positive fibroblasts were found to have a high degree of pluripotency. Therefore, by using the CD105 selected in the present invention, it can be utilized in the development of a method for selectively separating fibroblasts having stem cell function.