醒脑静治疗轻-中度颅脑外伤临床疗效评价

摘要

Objective To observe the clinical efficacy on Xingnaojing in treatment of mild to moderate traumatic brain injury, and to evaluate its safety and effectiveness. Methods 50 cases of patients with closed craniocerebral injury (GCS score 9-15 points) were divided into treatment group and control group with 25 cases in each by random number table. Patients in treatment group were treated with Xingnaojing on the basis of 20% mannitol, and patients in control group were treated with 20% mannitol only. Improvement of clinical symptoms such as absorption of hematoma under the scalp, headache, dizziness, nausea, vomiting, and memory disorders, etc. and adverse drug reaction conditions after 1 weeks of treatment of the two groups were evaluated. Results There were 23 cases in effective, 2 cases in ineffective in treatment group, and the effective rate was 92%. There were 12 cases in effective, 13 cases in ineffective in control group, and the effective rate was 48%. The total effective rate of the treatment group was significantly higher than that of the control group (χ2=11.520,P<0.05). The time of hematoma regression of the control group was significantly longer than that of the treatment group, the difference was statistically significant between the two groups (t=3.990,P<0.05). There were no skin rash, chills, fever and other allergic reactions in treatment group. Conclusion Xingnaojing combined with mannitol in treatment of mild to moderate traumatic brain injury has clinical accurate efficacy and good safety. It can significantly improve the brain injury caused by dizziness, nausea and other symptoms, and shorten the time to dissipate the hematoma of the scalp. It has high clinical application value.%目的：观察醒脑静对轻-中度颅脑外伤临床治疗效果，评价其安全性、有效性。方法将50例闭合性颅脑损伤患者（GCS评分9～15分），随机数字表法分为治疗组和对照组各25例，治疗组于20%甘露醇基础上加醒脑静治疗，对照组单用20%甘露醇治疗，两组于治疗1周后评定头皮下血肿吸收情况、头痛、头晕、恶心、呕吐、记忆障碍等临床症状改善及治疗不良反应情况。结果治疗组有效23例，无效2例，总有效率为92%；对照组显效12例，无效13例，总有效率为48%，治疗组总有效率显著高于对照组（χ2=11.520， P＜0.05）；对照组血肿消退时间明显长于治疗组，两组比较差异有统计学意义（t=3.990，P＜0.05）；治疗组无皮疹、畏寒、发热等过敏反应。结论醒脑静联合甘露醇治疗轻-中度颅脑损伤临床疗效确切，安全性好，能显著改善脑外伤后所致头晕、恶心等症状，缩短头皮下血肿消散时间，具有极高临床应用价值。