目的:探讨小剂量奥曲肽对肝硬化顽固性腹水的治疗效果.方法:选择我院2007 年1 月～2010 年12 月间收治的65 例肝硬化顽固性腹水患者,根据治疗方法的不同将其分为两组,对照组30 例患者行保肝、限制钠盐和水、补充白蛋白及使用利尿剂等常规治疗,观察组35 例患者在对照组治疗的基础上加用奥曲肽,治疗14 d 后比较两组临床疗效.结果:观察组治疗总有效率为88.6%,明显高于对照组56.7%的治疗有效率,且尿量及腹水减少量明显高于对照组,门脉压力较对照组明显降低,两组比较差异有统计学意义(P＜0.05).结论:小剂量奥曲肽是一种较为理想地消除肝硬化顽固性腹水的治疗方法.%Objective: To explore the treatment effect of low-dose Octreotide for cirrhosis with refractory ascites. Methods: 65 patients of cirrhosis with refractory ascites admitted to our hospital from January 2007 to December 2010 were randomly divided into two groups according to different methods of treatment. 30 patients in the control group were given the conventional treatment of protecting liver, limiting sodium and water, supplying albumin and using diuretics and so on, on the basis of control group, 35 patients of observation group plus Octreotide, 14 d after treatment the clinical efficacy were compared. Results: The total treatment efficiency of observation group was 88.6%, significant higher than 56.7% of control group, and the amount of urine and the reduce of ascites was significantly higher than control group, the differences between two groups were significant (P<0.05). Conclusion: Low-dose Octreotide is a more ideal to eliminate cirrhosis with refractory ascites treatment method.
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