Objective: To study the significance of the combined detection of pleural effusion ADA, LDH, and CEA on the differential diagnosis of benign and malignant pleural effusion. Methods: Conventional acquisited pleural effusion of 46 cases of patients with tuberculosis and 30 cases of patients with malignant disease, and ADA, LDH, CEA level were detected and analyzed. Results: The sensitivity, specificity, positive predictive value, negative predictive value of ADA>40 LJ/L, CEA<15 |jLg/L level as indicators to determine tuberculous pleural effusion were 85.71%, 90.19%, 78.94%, 90.19%; the sensitivity, specificity, positive predictive value, negative predictive value of ADA<40 LJ/L, CEA > 15 μg/L level as indicators of malignant pleural effusion to determine were 71.74%, 85.74%, 86.84%, 69.77%. Conclusion: Combined detection of ADA, CEA can help differential diagnosis of tuberculosis and malignant pleural effusion.%目的:研究联合检测胸腔积液中腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)和癌胚抗原(CEA)对胸腔积液良恶性鉴别的意义.方法:常规采集46例结核性疾病患者和30例恶性疾病患者的胸腔积液,检测ADA、LDH、CEA水平并进行分析.结果:ADA>40 U/L、CEA<15 μg/L水平作为判断结核性胸腔积液指标的敏感性、特异性、阳性预测值、阴性预测值为85.71%、90.19%、78.94%、90.19%;以ADA<40 U/L、CEA>15 μg/L水平作为判断恶性胸腔积液指标的敏感性、特异性、阳性预测值、阴性预测值分别为71.74 %、85.74%、86.84%、69.77%.结论:联合检测ADA、CEA两项指标有助于鉴别结核性和恶性胸腔积液.
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