三维适形放疗单用或与不同时段热疗联合治疗局部晚期非小细胞肺癌

摘要

目的:评价不同时段深部热疗联合三维适形放疗治疗局部晚期非小细胞肺癌(NSCLC)的临床疗效.方法:回顾性分析我院2006年9月~2010年3月采用三维适形放疗单用或与不同时段深部热疗联合治疗局部晚期 NSCLC患者 91例,其中,单纯行放疗组(A组)31例,放疗后即刻行热疗组(B组)37例,热疗后2 h行放疗组(C组)23例.完成治疗后0~2个月通过CT对近期疗效进行评价.结果:3组有效率分别为A组 51.6%,B组 75.7%和C组78.3%.B组与A组,C组与A组的有效率比较,差异有统计学意义(P<0.05);B组与C组的有效率比较,差异无统计学意义(P>0.05).结论:热疗联合三维适形放疗比单纯行三维适形放疗在治疗局部晚期NSCLC短期疗效上更具优势,而热疗联合放疗的时间和顺序对短期疗效无明显影响.%Objective: To evaluate the efficacy of thermotherapy combined with 3-D conformal radiotherapy in different time and sequence in the treatment of locally advanced non-small-cell lung cancer (NSCLC).Methods: 91 patients with locally advanced NSCLC were analyzed retrospectively, who were treated with 3-D conformal radiotherapy only or combined with thermotherapy in different time and sequence in our hospital from September 2006 to March 2010.31 patients were treated with 3-D conformal radiotherapy only (group A), 37 patients were treated with thermotherapy after 3-D conformal radiotherapy immediately (group B), 23 patients were treated with 3-D conformal radiotherapy after thermotherapy at an interval of about 2 hours (group C).The short-term effects were evaluated through CT scan after therapy of 0-2 months.Results: The effective rate of group A was 51.6％, and that of group B and group C was 75.7％ and 78.3％, the differences between group A and B, group A and C were significant (P＜0.05), and there was no significant difference between group B and C (P＞0.05).Conclusion: The patients treated with thermotherapy combined with 3-D conformal radiotherapy can obtain better short-term effects than those treated with 3-D conformal radiotherapy only.The interval time and sequence between thermotherapy and 3-D conformal radiotherapy have no significant impact to short-term effects.