Objective To explore the clinical significance of the level change of serum S100B protein, neuron enolase (NSE), soluble vascular endothelial cell adhesion molecules (sVCAM-1) and neuropeptide Y (NPY) in children with viral encephalitis. Methods 32 cases of children viral encephalitis with central nervous system infection were selected as the viral encephalitis group, and according to the illness was divided into light disease group and severe disease group, at the same time, 32 cases without central nervous system infection (by lumbar puncture) of children were chose as control group. S100B protein, NSE, sVCAM-1 and NPY level of the serum and cerebrospinal fluid in children were detected, and the results were compared. Results The levels of S100B protein, NSE, sVCAM-1 and neuropeptide Y (NPY) in the viral encephalitis group were obviously higher than those in the control group, there were significant differences (P < 0.05). For the viral encephalitis children, S100B protein, NSE, sVCAM-1 and neuropeptide Y (NPY) level in serum and cerebrospinal fluid were significantly lower in light disease group than those in severe group, there were significant differences (P < 0.05). Conclusion There is a correlation between the change and illness weight of viral encephalitis children cerebrospinal fluid and serum S100B protein, NSE, sVCAM-1 and neuropeptide Y level, which has an important value to judge the illness.%目的 探讨病毒性脑炎患儿脑脊液及血清中S100B蛋白、神经元烯醇化酶(NSE)、可溶性血管内皮细胞黏附分子(sVCAM-1)和神经肽Y(NPY)水平变化的临床意义.方法 选取32例有中枢神经系统感染的病毒性脑炎患儿为病毒性脑炎组,并根据病情分为轻症组和重症组,选择同期住院的经腰椎穿刺确定无中枢神经系统感染的病毒性脑炎患儿32例作为对照组.检测各组患儿血清和脑脊液中S100B蛋白、NSE、sVCAM-1和NPY的水平,并将结果进行比较.结果 病毒性脑炎患儿血清和脑脊液中S100B蛋白、NSE、sVCAM-1和神经肽Y水平明显高于对照组,两者比较,差异有统计学意义(P < 0.05).病毒性脑炎患儿轻症组血清和脑脊液中S100B蛋白、NSE、sVCAM-1和NPY水平明显低于重症组,两者比较,差异有统计学意义(P < 0.05).结论 病毒性脑炎患儿脑脊液及血清中S100B蛋白、NSE、sVCAM-1和NPY水平的变化与病情轻重有相关性,对判断病情有重要的临床价值.
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