急性心肌梗死患者血清中hs-CRP、cTnI、Myo及CK-MB的表达及其临床意义

摘要

Objective To investigate the clinical significance of detecting the hs-CRP, cTnI, Myo and CK-MB in serum of acute myocardial infarction patients. Methods 68 cases of patients with acute myocardial infarction were selected as the research objects (AMI group); 68 healthy cases were selected as the control group; myocardial enzymes of two groups were detected and compared. Results The hs-CRP, cTnI, Myo and CK-MB in serum were compared between two groups, there were significant differences (t value were 15.61, 10.25, 14.19, 4.35, P < 0.01 or P < 0.05). The hs-CRP was more sensitivity high than cTnI, Myo and CK-MB in AMI patients, the cTnl had the highest specificity. The 2, 4, 8 hours hs-CRP, cTnI and CK-MB gradually raised in AMI patients, and Myo raised to the peak in 4 hours then reduced gradually. Conclusion The united detection of hs-CRP, cTnI, Myo and CK-MB in serum has important value for diagnosis of acute myocardial infarction.%目的 探讨急性心肌梗死患者血清超敏C反应蛋白(hs-CRP)、肌钙蛋白(cTnI)、肌红蛋白(Myo)及肌酸激酶同工酶(CK-MB)检测的临床意义.方法 选取本院收治的68例急性心肌梗死患者为研究对象(AMI组),同时选取68例健康者为对照组,检测两组患者的心肌酶,并进行比较.结果 两组血清hs-CRP、cTnI、Myo及CK-MB比较,差异均有统计学意义(t值分别为15.61、10.25、14.19、4.35,P ＜ 0.01或P ＜ 0.05).AMI患者的血清hs-CRP的敏感性较cTnI、Myo及CK-MB高,其中cTnI的特异性为最高.AMI患者2、4、8 h血清hs-CRP、cTnI及CK-MB逐渐升高,而Myo于4 h左右达到最高峰后逐渐降低.结论 血清hs-CRP、cTnI、Myo及CK-MB联合检测对诊断急性心肌梗死具有重要的价值.