拉米夫定对HBV-DNA及HBeAg的影响研究

摘要

Objective To study the influence of Lamivudine on the HBV-DNA virus content and HBeAg in patients with viral B hepatitis. Methods A total of 87 patients with hepatitis B receiving Lamivudine treatment in our hospital were selected as the experiment group and 56 contemporary patients with hepatitis B receiving common live protection treatment were selected as the control group. The changes of HBV-DNA viral load and HBeAg in different treatment stages of the two groups were studied. Results The average log values of HBV-DNA before treatment between the two groups were not significantly different (P > 0.05); the average log values of HBV-DNA 3, 6 months and 1 year after treatment were all significantly different between the two groups (P < 0.01). The positive rates of HBV-DNA and HBeAg in different stages of the experiment group were significantly different (P < 0.01); the positive rates of HBV-DNA and HBeAg in different stages of the control group were not significantly different (P > 0.05). Conclusion Lamivudine has good clinical curative effects in the treatment of chronic hepatitis B.%目的 研究拉米夫定对乙型病毒性肝炎患者机体内HBV-DNA病毒含量及HBeAg的影响.方法选择我院87例拉米夫定治疗的乙肝患者为实验组,并以同期56例行一般护肝治疗的乙肝患者为对照组,研究两组不同治疗阶段HBV-DNA病毒载量及HBeAg的变化特点.结果两组治疗前HBV-DNA平均对数值经比较,差异无统计学意义(P > 0.05);治疗3、6个月及1年两组HBV-DNA平均对数值比较,差异均有高度统计学意义(P < 0.01);实验组HBV-DNA、HBeAg不同时期阳性率差异有高度统计学意义(P < 0.01),对照组HBV-DNA、HBeAg不同时期阳性率差异无统计学意义(P > 0.05).结论拉米夫定对慢性乙型肝炎有很好的临床疗效.