目的 观察丁苯酞氯化钠注射液联合注射用降纤酶治疗进展性卒中的疗效.方法 将120例急性进展性卒中患者随机分为治疗组(n=60)和对照组(n=60),治疗组在常规治疗的基础上加用丁苯酞氯化钠注射液25 mg(100mL)中静滴,2次/d,连用14 d,同时给予降纤酶10 U加入生理盐水250 mL静滴,1次/d,连用4 d,对照组在常规治疗的基础上只加用降纤酶,于治疗前及治疗第1、5、15天分别进行临床疗效及神经功能缺损评分.结果 两组于治疗前后神经功能缺损评分、临床疗效均有改善,治疗组总有效率为88.33%,对照组总有效率为73.33%,治疗组改善更明显,与对照组相比差异有统计学意义(P<0.05).结论 丁苯酞氯化钠注射液联合降纤酶治疗进展性卒中疗效确切,不良反应少,值得推广.%Objective To observe the clinical effect of treatment of progressive stroke with Butylphthalide and Sodium Chloride Injectionand defibrase. Methods 120 patients with progressive stroke were randomly divided into two groups, treatment group (n=60) and control group (n=60). With same normal basic treatment between the two groups, the treatment group was intravenous injected with Butylphthalide and Sodium Chloride injection 25 mg (100 mL), twice a day for 14 days. Meanwhile, they were injected with defibrase 10 U into 250 mL normal saline, once a day, for 4 days. The control group was treated with defibrase only. 'The neural function deficits and the clinical curative effects before the treatment and on the 14th day after the treatment were observed. Results The neural function deficits evaluation indicates that the improvements of the two groups after the treatment, especially of the treatment group. The total effective rate was 88.33% In the treatment group and 73.33% in there was significant difference on the total effective rate between the two groups (P < 0.05). Conclusion It Is effective of Butylphthalide and Sodium Chloride Injection and defibrase on the treatment of stroke Inprogression, which has fewer side effects and is worthy of application.
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