舍曲林治疗心肌梗死后抑郁患者的疗效观察

摘要

目的 观察舍曲林治疗心肌梗死后抑郁的临床疗效.方法 75例患者随机分成两组,观察组(38例)在常规心脏药物治疗的基础上,予以盐酸舍曲林片50 mg/次,1次/d;对照组(37例)予以盐酸氯丙咪嗪片,初始剂量为25 mg/次,2次/d,1周内根据病情增量,最大剂量为150 mg/d,8周为1个疗程.观察两组患者的临床疗效及不良反应.结果 观察组总显效率为63.1%,对照组为48.7%,差异有统计学意义(P<0.05).治疗结束时观察组TESS评分为(1.8±0.5)分,对照组为(4.0±1.7)分,两组比较差异有高度统计学意义(P<0.01).结论 舍曲林治疗急性心肌梗死(AMI)后抑郁疗效好,且能克服氯丙咪嗪不良反应多、剂量大、耐受性差等缺点.%Objective To observe the efficacy of Seriraline in the treatment of patients with AMI and depression. Methods 75 patients were randomly divided into two groups, conventional heart medications were given to all patients,the observation group (38 cases) on the basis of this, Sertraline Hydrochioride Tablets 50 mg were given one time a day; the control group 37 cases received Clomipramine Hydrochioride Film treaetment, the initial dose of 25 mg for each time, 2 times a day, according to the disease within a week increments, the maximum dose of 150 mg/d. The clinical efficacy and adverse reactions were observed. Results The total excellence rate was 63.1% in the observation group, 48.7% in the control group, the difference was statistically significant (P < 0.05). Ending of treatment, TESS score was (1.8±0.5) scores in the observation group, (4.0±1.7) scores in the control group, the difference was statistically significant (P< 0.01). Conclusion Sertraline in the treatment of depression after AMI is effective, and overcome the adverse reactions, large dosage, defects and poor tolerability of Clomipramine.