冠心病患者幽门螺杆菌感染状况相关性研究

摘要

Objective To investigate the relationship of helicobacter pylori (Hp) infection and coronary heart disease (CHD), and to know more about the function of Hp infection in invasion of coronary heart disease. Methods The serum Hp-IgG antibodies were measured by ELISA in 144 patients with CHD (CHD group) and 96 healthy persons (non-CHD group). Cy-totoxin associated protein A (CagA) antibodies were tested by western-blot assay in patients with Hp infection. Endothelin-1 (ET-1) was tested by RIA. The differences between CHD patients with Hp infection and without Hp infection were compared. Results ①Prevalence of Hp-IgG was higher in CHD group (60.4%) than in non-CHD group (41.7%) (P < 0.05). Removing common risk factors, Hp infection still could increase the danger of CHD (OR=2.O9, 95%C7 1.48-3.00). (2)Hp CagA+ could increase the danger of CHD, while CagA- didn't increase the danger of CHD obviously. (3)In CHD group, the level of ET-1 in patients with Hp infection was higher than that of patients without Hp infection (P < 0.05). Conclusion Hp infection is a risk factor for CHD. CagA+ infection may increase the danger of CHD. The level of ET-1 in patients with Hp infection is improved obviously.%目的 探讨幽门螺杆菌(helicobacter pylori,Hp)感染与冠状动脉粥样硬化性心脏病(CHD)二者的关系,进一步了解Hp 感染在冠心病发病中的作用.方法 针对144例冠心病患者(冠心病组)和96例健康体检者(非冠心病组),用ELISA 方法检测血清中的抗Hp-IgG,采用Western-blot 方法检测Hp 感染阳性患者血清中的抗CagA 抗体,用放射免疫法测定冠心病组内皮素-1(ET-1),比较合并Hp 感染的冠心病患者与非Hp 感染者之间的差异.结果 ①冠心病组抗Hp-IgG 阳性率(60.4%)明显高于非冠心病组(41.7%)(P < 0.05),去除常见的危险因素后,Hp 感染仍能增加患冠心病的危险性(OR=2.09,95%CI 1.48～3.00).②Hp CagA+毒力亚型感染增加患冠心病的危险性,而CagA-毒力亚型感染并未明显增加患冠心病的危险性.③冠心病组Hp 感染者血浆ET-1 水平显著高于非Hp 感染者(P < 0.05).结论 Hp 感染是冠心病危险因素,CagA+毒力亚型感染可能更增加患冠心病的危险性,Hp 感染患者血浆内皮素水平显著升高.