S-100B检测对急性脑出血患者临床预后的评估价值研究

摘要

目的 通过观察急性脑出血患者血清S-100B蛋白的动态变化,分析其与脑出血患者临床症状、体征及预后之间的关系.方法 应用酶联免疫吸附测定法对80例急性脑出血患者及80例对照的血清S-100B蛋白水平进行动态检测及比较;应用CT测定出血体积并于发病1个月后用格拉斯哥预后评分(GOS)评估预后.结果 急性脑出血患者血清S-100B蛋白浓度第1天开始升高,第3天达到高峰,第7、10天较其他时间明显下降,仍显著高于恢复期及对照组(P＜0.05).其浓度与出血量有明显的相关性(P＜0.05),且S-100B蛋白含量随疾病的严重程度的增加而升高(P＜0.05).结论 S-100B可作为急性脑出血患者脑损伤早期敏感的检测指标,并对患者的预后评价具有重要的临床价值.可将S-100B蛋白测定作为脑出血早期诊断和估计预后的动态观察指标.%Objective To observe the dynamic change of acute cerebral hemorrhage patient serum S-100B protein,and analyze the relationship of the clinical symptoms,signs and the prognosis of the patients with cerebral hemorrhage.Methods Serum S-100B protein of 80 cases of patients with acute cerebral hemorrhage and 80 patients of control group were dynamic measurement by using ELISA method and compared,bleeding volume were detected by CT,and after 1 month the prognosis was assessed with the Glasgow outcome score (GOS).Results For the patients with acute cerebral hemorrhage,blood serum S-100B protein concentration in the first day began to increase,the third days reached the peak,the seventh,tenth day over the other time decreased,was significantly higher than the recovery period and the control group (P ＜ 0.05).The concentration and the amount of bleeding significantly correlated (P ＜ 0.05),and S-100B protein content increased with the severity of the disease increased (P ＜ 0.05).Conclusion S-100B can be early sensitive index of brain injury in patients with acute intracerebral hemorrhage,and the prognosis for the patient evaluation has important clinical value.S-100B protein could be as an early dynamic observation index of cerebral hemorrhage diagnosis and prognosis estimation.