Serum S-100B Protein as a Prognostic Factor in 112 Patients with Severe Traumatic Brain Injury

摘要

We studied the prognostic power of serum protein S-100B in 112 severe traumatic brain injury (TBI) patients (>14 years, between 6/ 2000-7/2002). Demographic and clinical data were as follows: male 78%; median age 35 years, road traffic accident 67%, multi-trauma 42%, admission GCS 3 in 20%; 4 in 20%; 5 in 12%; 6 in 14%; 7 in 22%; 8 in 12%, unilateral pupillary dilatation 27%, bilateral fixed pupils 31%, admission CT by Marshall I in 1%; II in 19%; El in 16%; IV in 8%; VI in 56%, craniotomy 50%, barbiturate treatment 26%. One-year GOS was 1 in 56%; 2 in 2%; 3 in 5%; 4 in 25%; 5 in 12%. Logistic regression analysis showed mat high S-100B was an independent predictor of bad outcome (p=0.032). We concluded that S-100B protein is a reliable prognostic factor of die outcome in severe TBI.