Objective:To evaluate the diagnostic value of high sensitive C reactive protein(,hs-CRP) procalcitonin(PCT), and immune function in children with pneumonia.Methods: 200 children with pneumonia from July 2014 to July 2015 in the hospital were collected, and were divided into three groups according to the kinds of pathogens infection: bacterial pneumonia group (70 cases), mycoplasma pneumonia group (65 cases) and viral pneumonia group (65 cases). And 40 cases of earlier outpatient health physical examination were selected as healthy control group. Blood samples in the four groups were collected, and the hs-CRP, PCT and immune function were compared.Results: The levels of hs-CRP in the 4 groups were compared, and the level of hs-CRP in the bacterial pneumonia group was higher than that in the other 3 groups (t=2.358,t=3.062,t=2.816;P<0.05). The level of hs-CRP in mycoplasma pneumonia group was higher than that in the control group (t=3.128,t=3.752;P<0.05). There was no significant difference between viral pneumonia group and the control group (P>0.05). The level of PCT in bacterial pneumonia group was higher than that in other three groups (t=2.613,t=2.774,t=5.273;P<0.05) and the positive cases of PCT in bacterial pneumonia group was higher than that in other three groups (x2=24.67,P<0.05). CD4+ in 3 groups of pneumonia patients were lower than those in the control group (t=3.687,t=6.204,t=2.379;P<0.05). CD4+/CD8+ in 3 groups of pneumonia patients were lower than those in the control group (t=2.083,t=3.068,t=6.297;P<0.05). Treg CD4+CD25+ in 3 groups of pneumonia patients were lower than those in the control group (t=7.104, t=2.339,t=2.621;P<0.05). Compared with the control group, CD8+ of the bacterial and mycoplasma pneumonia group was higher (t=3.255,t=2.694;P<0.05).Conclusion: The combined detection of hs-CRP, PCT and immune function can be used in early diagnosis of pneumonia in children, and it is beneficial to the prognosis of the patients.%目的：探讨发光免疫分析仪联合检测超敏C反应蛋白(hs-CRP)、降钙素原(PCT)和免疫功能在小儿肺炎诊断中的价值。方法：选取200例肺炎患儿，按感染的病原体种类将其分为细菌性肺炎组(70例)，支原体肺炎组(65例)和病毒性肺炎组(65例)，同时选取40名健康体检儿童为健康对照组，采集4组血样，采用发光免疫分析仪联合检测，并比较4组的hs-CRP、PCT和免疫功能。结果：4组hs-CRP水平进行比较，其中细菌性肺炎组患儿hs-CRP水平高于其他3组，差异有统计学意义(t=2.358，t=3.062，t=2.816；P＜0.05)；支原体肺炎组患儿hs-CRP高于病毒性肺炎组患儿与健康对照组，差异有统计学意义(t=3.128，t=3.752；P＜0.05)；病毒性肺炎组与对照组比较，无统计学差异。细菌性肺炎组患儿的PCT水平显著高于其他3组，差异有统计学意义(t=2.613，t=2.774，t=5.273；P＜0.05)；而阳性率也显著高于其他3组，差异有统计学意义(x2=24.67，P＜0.05)。3组肺炎患儿CD4+低于健康对照组，差异有统计学意义(t=3.687， t=6.204，t=2.379；P＜0.05)；CD4+/CD8+低于健康对照组，差异有统计学意义(t=2.083， t=3.068，t=6.297；P＜0.05)；CD4+CD25+Treg低于健康对照组，差异有统计学意义(t=7.104， t=2.339，t=2.621；P＜0.05)。细菌性肺炎组和支原体肺炎组的CD8+高于健康对照组，差异有统计学意义(t=3.255，t=2.694；P＜0.05)。结论：发光免疫分析仪联合检测hs-CRP、PCT和免疫功能可以用于儿童肺炎的早期鉴别诊断，并有利于患儿预后。
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