基于FastMap算法的类风湿病通路基因在1号染色体上的连锁特性的研究

摘要

本文阐述了应用FastMap算法研究类风湿病通路基因在1号染色体上的连锁特性的方法和结果。结果发现，在FGF Signaling in Rheumatoid Arthritis通路中，CTSB、PRKC、ACAT2和MAPK1出现了相似的连锁特性。在IFN Signaling in Rheumatoid Arthritis通路中，IL15、HLA-DR和HLA-DQA1出现了相似的连锁特性。在IL10 Signaling in Rheumatoid Arthritis通路中，HLA-DR和TGFB1，CXCR4和CD86出现了相似的连锁特性。该结果说明同一通路中的基因存在相似的连锁特性，这些基因可能具有潜在的相似功能。%This paper introduced the methods and results of the research on linkage characteristics of rheumatoid arthritis pathway genes located in chromosome 1 by using FastMap algorithm. The results showed that there were similar linkage characteristics among genes including CTSB, PRKC, ACAT2 and MAPK1 in FGF Signaling in Rheumatoid Arthritis pathway and there were similar linkage characteristics among genes including IL15, HLA-DR and HLA-DQA1 in IFN Signaling in Rheumatoid Arthritis pathway while there were similar linkage characteristics between genes including HLA-DR and TGFB1 as well as CXCR4 and CD86 in IL10 Signaling in Rheumatoid Arthritis pathway. The results indicated that the potential functions of the genes with similar linkage characteristics in the same pathway may be similar.