[Objective] To explore the significance of arteriolar hypertrophy in IgA nephropathy. [Methods] A case control study was carried out in 93 cases with IgA nephropathy (2002.3～2003.8) diagnosed by renal biopsy in our department. Univariate analysis and multivariate logistic regression analysis were performed to analyze the clinical and pathologic materials of 93 IgAN patients. [Results] Of the 93 IgAN patients, 59.1% were with arteriolar hypertrophy. Among these patients, 63.6% were mild arteriolar hypertrophy; 27.3% were moderate arteriolar hypertrophy; 9.1% were severe arteoliar hypertrophy. The patients with arteoliar hypertrophy had a relatively severe condition than those without arteriolar hypertrophy (P ＜0.01). The patients with severe arteoliar hypertrophy had more severe condition than those with mild or moderate arteoliar hypertrophy (P ＜0.01). The higher the pathological grade of the nephropathy, the more severe the arteoliar lesions (P ＜0.01). Multivariate logistic regression analysis showed that the significant influencing factors on arteoliar hypertrophy included hypertension, high serum creatinine, global glomerular sclerosis (≥50%), interstitial inflammation (≥50%). [Conclusions] In patients with IgAN, arteriolar hypertrophy can reflect the disease degree and can be used as an important histological prognostic indicator.%目的探讨IgA肾病肾小动脉增厚的意义.方法对93例IgA肾病临床病理资料进行回顾性病例对照研究,运用单因素和多因素方法分析IgA肾病患者的临床指标及病理改变与肾小动脉增厚的关系.结果93例IgA肾病患者中有小动脉增厚者占59.1%,其中轻度占63.6%,中度占27.3%,重度占9.1%.肾小动脉重度增厚的患者临床病情和病理改变较肾小动脉轻度和中度增厚者严重(P＜0.01);多因素分析显示高血压、血肌酐增高、球性硬化(≥50%)、间质炎性细胞浸润≥50%对IgA肾病小动脉增厚的发生影响有显著意义.结论IgA肾病肾小动脉增厚能够反映病变的程度,可以作为判断预后的一个重要病理指标.
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