IL-36γ、p38 MAP K通路和 Th17细胞因子在扁平苔藓中的表达

摘要

目的：检测IL-36及p38丝裂原活化蛋白激酶( p38MAPK)通路和Th17细胞因子在扁平苔藓中的表达。方法：应用Envision免疫组化法检测58例扁平苔藓及19名正常皮肤标本中IL-36γ、磷酸化-p38MAPK( p-p38)和IL-17A的表达。结果： IL-36γ、p-p38和IL-17A在扁平苔藓皮损中的蛋白表达阳性率为86.21％、79.31％和94.83％，显著高于正常对照标本阳性率为68.42％、15.79％和63.16％(均P<0.01)。扁平苔藓组中，IL-36γ与p-p38、IL-36γ与IL-17A的表达水平存在显著正相关(P<0.001)，两因子表达强度有显著差异(P<0.05)。结论： p38MAPK通路和Th17细胞因子可能与扁平苔藓的发病有关。%Objective:To detect the expression of IL-36, p38 mitogen-activated protein kinase ( p-p38) pathway and Th17 cytokine in lichen planus. Methods:Immunohistochemistry EnVision technique was used to detect the expression of IL-36γ, p-p38 and IL-17A in 58 patients with lichen planus and 19 controls. Re-sults:The expression of IL-36γ, p-p38 and IL-17A was higher in the patients’ lesion of lichen planus ( the positive rates were 86.21%, 79.31% and 94.83%) than in control group (the positive rates were 68.42%, 15.79% and 63.16%) ( all P<0.01) . In lichen planus group, there were positive correlations between the ex-pression of IL-36γand p-p38 ( P<0.001) , and between the expression of IL-36γand IL-17A ( P<0.001) . Significant difference was also observed between the two cytokines’ expression grade ( P<0.05) . Conclusion:p38MAPK pathway and Th17 cytokine may be involved in the pathogenesis of lichen planus.