目的：：对关节病型银屑病与强直性脊柱炎的易感基因进行关联分析,以期发现共同的易感基因。方法：以379例关节病型银屑病( PsA)、595例寻常型银屑病( PsV)及806例健康对照为样本,以Sequenom MassARRAY系统为平台,对全基因组关联研究发现的强直性脊柱炎的9个易感基因SNP位点进行基因分型和数据分析。结果： ERAP1基因(rs27037,P＝6.66×10－5,OR：1.43)、21q22.2(rs2242944,P＝1.07×10－3,OR：0.73)及IL23R基因(rs1004819,P＝4.58×10－3,OR：1.28)与PsA相关。ERAP1( rs27037,P＝1.56×10－4,OR：1.35)与PsV相关。 ERAP1基因对于PsA和PsV的患病风险无差异。 IL23R基因( rs1004819)及21q22.2( rs2242944)在PsA和PsV患病风险上存在中等程度的异质性(I2值分别为57.41和71.20),但P值无明显差异(>0.05)。IL23R基因(rs11209032,P＝1.57×10－3,OR：1.52)与PsA脊柱炎相关。结论： ERAP1基因、21q22.2区域及IL23R基因是PsA与强直性脊柱炎共有的易感基因。%Objective:To determine the susceptibility loci of ankylosing spondylitis found by GWAS in pa￣tients with psoriatic arthritis ( PsA) . Methods:Nine susceptibility SNPs of ankylosing spondylitis were geno￣typed in 379 patients with PsA, 595 patients with psoriasis vulgaris ( PsV) and 806 healthy controls by Se￣quenom MassARRAY. Results: ERAP1 ( rs27037, P = 6. 66 × 10-5 , OR:1. 43 ) , chromosome 21q22. 2 (rs2242944, P=1.07×10-3, OR:0.73)and IL23R (rs1004819, P=4.58×10-3,OR:1.28)were significant association with susceptibility of PsA. ERAP1 (rs27037, P=1.56×10-4,OR:1.35) associated with PsV. There was no heterogeneity of ERAP1( rs27037) between PsA and PsV groups and there was a heterogeneity of chromosome 21q22.2 ( rs2242944) and IL23R ( rs1004819) between them. IL23R( rs11209032) was found to be associated with axial PsA (P=1.57×10-3,OR:1.52). Conclusion: ERAP1, 21q22.2 domain and IL23R are common susceptibility genes of both PsA and ankylosing spondylitis.
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