复发性生殖器疱疹sHLA-G及外周血T细胞亚群和NK细胞的表达

摘要

Objective:To determine the change of the level of T lymphocyte subsets, NK cells plasma and sHLA-G in the patients with recurrent genital herpes ( RGH) before and after treatment. Methods:The level of plasma sHLA-G was detected by the enzyme linked immunosorbent assay and the levels of T lymphocyte subsets and NK cells were detected by the flow cytometry in 60 patients. Results:The level of NK cells in the patients before and after treatment was (15.01±5.89) % and (17.72±5.56) %, with a significant difference (P<0.05). The level of sHLA-G was (11.03±14.57) U/mL and (0.41±0.45) U/mL, with a significant difference ( P<0.05) . There was no significant difference in the levels of CD3+ T cells, CD4+T cells, CD8+T cells and CD4+/CD8+ in the patients before and after treatment. Conclusion:sHLA-G and NK cells may be related to the development of RGH.%目的: 明确复发性生殖器疱疹( RGH)患者治疗前后外周血T细胞亚群和NK细胞及sHLA-G水平变化. 方法: 采用酶联免疫吸附法和流式细胞仪分别检测60例RGH患者治疗前后血浆sHLA-G水平及外周血T细胞亚群和NK细胞表达. 结果: RGH患者血浆sHLA-G水平治疗前后分别为(11.03±14.57) U/mL和(0.41±0.45) U/mL,差异有统计学意义(P<0.05);NK细胞治疗前后分别为(15.01±5.89)% 和(17.72±5.56)%,差异有统计学意义(P<0.05). CD3+T细胞、CD4+T细胞、CD8+T细胞及CD4+/CD8+治疗前后差异无统计学意义( P>0.05). 结论: 外周血sHLA-G及NK细胞表达可能与RGH患者病情发展有关.