Elimination of PD-L1-positive malignancies by PD-L1 chimeric antigen receptor-expressing NK cells (ELIMINATION OF PD-L1-POSITIVE MALIGNANCIES BY PD-L1 CHIMERIC ANTIGEN RECEPTOR-EXPRESSING NK CELLS)

摘要

A composition of NK-92™ cells expressing a combination of PD-L1 CAR, CD16 and IL2, and using such cells to reduce tumor cells and cells in the tumor microenvironment (eg, MDSC or TAM) and treat cancer A method of doing is provided herein.