副肿瘤综合征相关性视神经病变的研究进展

摘要

Paraneoplastic syndrome are complexes of signs and symptoms in cancer-bearing patients resulting from dysfunction of tissues remote from the site of a malignant neoplasm or its metastases.Paraneoplastic optic neuropathy is rare and heterogeneous,as a group of disorders occurring in the setting of systemic malignancy.Timely recognition of one of these entities can facilitate early detection and treatment of an unsuspected,underlying malignancy,sometimes months before it would have otherwise presented,and gives the patient an increased chance at survival.%副肿瘤综合征指在某些恶性肿瘤或潜在恶性肿瘤患者体内,肿瘤细胞产生与释放生理活性物质,或引起机体自身免疫而导致的一组临床症状.副肿瘤综合征相关性视神经病变十分少见但是临床表现多样,可由于早期视功能障碍而就诊,有时可以提前数月发现原发肿瘤病灶,因而得到及时的诊断及治疗,有效的提高患者的生存率.本文总结了副肿瘤综合征相关性视神经病变的临床表现,发病机制及治疗策略.