丹参川芎嗪注射液对糖尿病肾病尿白蛋白/肌酐排泄率的影响

摘要

目的：观察丹参川芎嗪注射液对糖尿病肾病的临床疗效。方法60例糖尿病肾病患者随机分为实验组和对照组，两组采取同样控制饮食、血压、血糖、血脂的基础治疗方案，实验组加用丹参川芎嗪注射液2周，对治疗前后两组患者的一般资料、尿素氮（BUN）、血肌酐（Scr）、尿白蛋白/肌酐排泄率（uACR）等指标进行比较分析。结果治疗2周后实验组 Scr、uACR 低于对照组（P ＜0.05），两组 BUN 水平在治疗前后比较无统计学意义（P ＞0.05）。结论丹参川芎嗪注射液可以降低糖尿病肾病患者的 Scr、uACR，对肾脏具有保护作用。%Objective To investigate the clinical therapeutic effect of salviae miltiorrhizae ligustrazine hydrochloride injection to type 2 diabetic nephropathy. Methods A total of 60 patients with diabetic nephropathy were randomly divided into experimental group and control group. The patients in two groups were treated with conventional therapy,such as control diet,fasting blood sugar,blood pressure,cholesterol. In addition to,30 cases in the experimental group were treated with salviae miltiorrhizae ligustrazine hydrochloride injection once daily for two weeks. Before and after treatment, respectively,the related indexes in 60 cases were analysed with statistical methods including personal general information,physical examination and blood urea nitrogen(BUN),serum creatinin(Scr),urinary albumin-to-creatinine ratio(uACR). Results After two weeks,Scr,uACR in experimental group were decreased than control group(P < 0.05). Before and after treatment,respectively,general information,BUN were not statistical significance(P > 0.05)in the two groups. Conclusion In treatment of diabetic nephropathy,salviae miltiorrhizae ligustrazine hydrochloride injection can reduce Scr,uACR effectively to protect the function of kidney and retard the progression of diabetic nephropathy.