超临界流体强制分散溶液技术制备叶黄素超细微粒

摘要

以二氯甲烷为溶剂,以超临界二氧化碳为抗溶剂,采用超临界流体强制分散溶液(SEDS)过程对天然叶黄素进行了超细化研究.粒径约50μm的块状叶黄素晶体经SEDS过程处理后变为粒径3～20μm的棒状、缠绕纤维状的超细微粒.利用扫描电镜和光学显微镜分析测试了叶黄素超细微粒的粒径和形态,详细讨论了溶液浓度,溶液流量,压力和温度等操作参数对叶黄素超细微粒的粒径和形态的影响.结果表明溶液浓度,溶液流量和温度对超细微粒的粒径影响较大,而压力基本没有影响.%The micronization of natural lutein was carried out using dichloromethane as solvent and carbon dioxide as antisolvent via the Solution Enhanced Dispersion by Supercritical Fluids (SEDS) technology.The nubbly lutein crystals of 50μm diameters were successfully micronized by the SEDS process to rod-like or twisted fiber-like microparticles with 3 ～ 20μm diameters.Morphologies and particle sizes (PSs) of lutein microparticles were analyzed by the scanning electron microscopy and optical microscopy.The influences of operating variables include initial solution concentration and flow rate,pressure and temperature on PSs and morphologies of the lutein microparticles obtained by the SEDS-PA process were discussed.The results shown that the effects of temperature,initial solution concentration and flow rate on PS of the lutein microparticles were more significant,while the pressure had little effects on PSs.