Objective To observe the degree of continuous pumping well combined albumin nida, paclitaxel and cisplatin regimen for advanced squamous cell carcinomas of the curative effect and adverse reaction. Methods Confirmed by pathological histology and cytology, there were 22 cases of patients with adanced squamous cell carcinomas, adopting continuous pumping 3 mg/days for pumping well degree, 1 to 7 days, albumin 200 mg/m2 taxol, the first day. nida's platinum 60 mg/m2, 2 day, 1 cycle per for 21 days, evaluation of curative effect and adverse reaction after 3 cycles of chemotherapy.Results 22 cases of patients with adanced squamous cell carcinomas, without CR, PR 9 cases, 12 cases SD, PD in 1 case, total effective rate (RR) and 40.91% clinical stability factor of 95.45%. Evaluation of adverse reaction, mainly in bone marrow suppression: leukopenia Ⅲ to Ⅳdegree 3 cases, 3 cases of thrombocytopenia Ⅲ to Ⅳ degrees after corresponding treatment all can restore, gastrointestinal reaction are Ⅰ to Ⅱ,Ⅲ to Ⅳ only in 2 cases, no kidney function damage, a mild to moderate body bone pain.Conclusion The degree of continuous pumping well combined albumin nida, paclitaxel and cisplatin regimen for advanced squamous carcinoma has a good curative effect, can improve the life quality and prolong the survival time, easily in the tolerance of adverse reaction.%目的 观察持续泵入恩度联合白蛋白紫杉醇及奈达铂方案治疗晚期鳞癌的疗效及毒副反应.方法 经病理组织学或细胞学证实的22例晚期鳞癌患者,采用持续泵入恩度3 mg/d持续泵入,第1～7 d,白蛋白紫杉醇200 mg/m2;奈达铂60 mg/m2,第2 d,每21 d为1周期,化疗3周期后评价疗效及毒副反应.结果 22例晚期鳞癌患者均可评价,无CR,PR 9例,SD 12例,PD 1例,总有效率(RR)40.91%,临床稳定率95.45%.毒副反应评价,主要为骨髓抑制:白细胞减少Ⅲ～Ⅳ度3例,血小板减少Ⅲ～Ⅳ度3例经相应处理后均可恢复,胃肠道反应均为Ⅰ～Ⅱ,Ⅲ～Ⅳ仅2例,无肝肾功能损害,有轻至中度的全身骨痛.结论 持续泵入恩度联合白蛋白紫杉醇及奈达铂方案治疗晚期鳞癌有较好疗效,可改善生活质量,延长生存时间,毒副反应轻易于耐受.
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