环磷酰胺冲击治疗肾病综合征型紫癜性肾炎患儿的疗效观察

摘要

目的：观察环磷酰胺（CTX）静脉冲击治疗肾病综合征型紫癜性肾炎（HSPN）的疗效。方法将15例临床表现为肾病综合征型HSPN患儿，给予CTX静脉冲击治疗，随访6～12个月。结果冲击治疗后8例完全缓解，5例部分缓解，2例无效，总有效率86.7%；治疗前后24 h尿蛋白定量相比差异具有统计学意义（P＜0.05）。结论CTX冲击联合激素治疗肾病综合征型HSPN疗效好，不良反应少。%Objective Observation of cyclophosphamide (CTX) intravenous pulse therapy of nephrotic syndrome purpuric nephritis (HSPN) effect. Methods of 15 cases clinical manifestations in children with nephrotic syndrome by HSPN, CTX pulse therapy 6-12 months of follow-up.Results Impact treatment of 8 patients after complete remission, 5 cases of partial remission, 2 invalid, the total effective rate 86.7%, 24h before and after treatment of urinary protein difference statistically significant (P<0.05). Conclusion CTX impact combined with hormone treatment of nephrotic syndrome-HSPN efifcacy, adverse reactions are less.