目的：探讨肺泡灌洗液中抵抗素样分子β在评估 ARDS 中的临床价值。方法选取35例重症感染性肺炎患儿，根据其是否符合ARDS、RF 诊断标准，分为重症肺炎并 ARDS 组（12例）、重症肺炎并 RF 组（12例）、重症肺炎组（10例）。检测肺泡灌洗液中抵抗素样分子β、氧合指数、小儿危重病例评分等，比较三组之间的差异。ARDS 组于插管5天复查上述指标并行前后比较。结果三组比较， RELMβ水平、Pa（02）／ Fi02、PCIS 分值存在显著性差异（均P ＜0.05或0.01）；ARDS 组患儿插管5天时，好转组 RELMβ水平低于未愈组（P ＜0.05）；RELMβ水平与 Pa（02）／ Fi02、PCIS 均呈负相关（r=-0.431、-0.395，P 均＜0.05）。结论抵抗素样分子β水平的检测有助于 ARDS 患儿病情严重程度的判断和预后评估。%Objective To explore the clinical value of BALF RELMβin prediction of ARDS induced by severe infectious pneumonia. Methods 35 children with severe infectious pneumonia were enrolled in the study and divided into ARDS group(12 cases), RF group (13 cases) and severe pneumonia group (10 cases) depending on the diagnostic criteria of ARDS or RF. BALF RELMβ, Pa (02) / Fi02 , PCIS were tested and their differences compared.Above indexes of ARDS group were reexamined 5 days after endotracheal intubation and compared with the former results . Results The RELMβlevel, Pa (02) / Fi02 and PCIS value showed significant differences ( P<0.05 or 0.01).The RELMβ level of improving cases was lower than the unhealed cases in ARDS group 5 days after the endotracheal intubation (P<0.05). RELMβlevel were negatively correlated with Pa (02) / Fi02 and PCIS (r=-0.431, -0.395, P<0.05).Conclusion The measurement of BALF relmβ can help to evaluate the severity and prognosis of ARDS children.
展开▼
